Rubiáceas brasileiras com potencial anti-inflamatório

Authors

  • Ana Paula Azevedo Barros da Silva
  • Dionys de Souza Almeida
  • Ana Maria Sampaio Assreuy
  • Renildo Moura da Cunha

DOI:

https://doi.org/10.55905/rdelosv17.n56-001

Keywords:

rubiáceas, inflamação aguda, mediadores inflamatórios, produtos naturais, Brasil

Abstract

A busca por novas estratégias terapêuticas para tratar doenças inflamatórias, com foco em produtos naturais como ferramentas alternativas tem aumentado. Este manuscrito revisa espécies brasileiras pertencentes à família Rubiaceae, com seus respectivos fitoconstituintes que apresentam atividades e mecanismos anti-inflamatórios em modelos experimentais. Para a busca foram utilizadas as bases de dados eletrônicas Web of Science, Pubmed, Science Direct e “Periódicos CAPES” e os sites World Flora Online Plant List e Reflora para verificar a ocorrência da planta no Brasil. Sessenta e cinco (65) manuscritos foram selecionados contemplando 39 espécies. Muitas espécies de Rubiaceae exibem atividades farmacológicas através da inibição de citocinas, mediadores derivados de lipídios e enzimas, entre outros mediadores do processo inflamatório. Nossos achados revelam Uncaria tomentosa e Morinda citrifolia como as mais estudadas. Assim, esta revisão fornece atualizações importantes sobre estas espécies ressaltando-as como fontes promissoras de compostos para o desenvolvimento de novos e complementares medicamentos anti-inflamatórios.

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Published

2024-06-06

How to Cite

Silva, A. P. A. B. da, Almeida, D. de S., Assreuy, A. M. S., & Cunha, R. M. da. (2024). Rubiáceas brasileiras com potencial anti-inflamatório. DELOS: Desarrollo Local Sostenible, 17(56), e1492. https://doi.org/10.55905/rdelosv17.n56-001

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